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Flights from Des Moines to Buffalo

Airlines operating flights from Des Moines to Buffalo

Choose from 1 airlines flying from Des Moines to Buffalo, including Delta Air Lines, and . Allegiant Air currently offers the cheapest ticket on this route.
Delta Air Lines logo Delta Air Lines

Find the cheapest flight options from Des Moines to Buffalo over the next three months. Book one-way tickets from THB 4,265 and round-trip tickets from THB 6,994.

      • DSM 11:42
        6h 34m
        1 stop
        BUF 19:16
        Des Moines - Buffalo | Sat, Jan 17 | American Airlines
        BUF 07:30
        4h 42m
        1 stop
        DSM 11:12
        Buffalo - Des Moines | Sat, Jan 24 | American Airlines
        THB 6,994 THB 12,160
        42% OFF
        42% OFF
        THB 12,160 THB 6,994
      • DSM 17:01
        5h 47m
        1 stop
        BUF 23:48
        Des Moines - Buffalo | Fri, Jan 30 | American Airlines
        BUF 05:12
        8h 34m
        1 stop
        DSM 12:46
        Buffalo - Des Moines | Mon, Feb 2 | American Airlines
        THB 8,466 THB 12,160
        30% OFF
        30% OFF
        THB 12,160 THB 8,466
      • DSM 16:25
        6h 16m
        1 stop
        BUF 23:41
        Des Moines - Buffalo | Thu, Jan 15 | American Airlines
        BUF 17:27
        5h 44m
        1 stop
        DSM 22:11
        Buffalo - Des Moines | Thu, Jan 22 | American Airlines
        THB 9,103 THB 12,160
        25% OFF
        25% OFF
        THB 12,160 THB 9,103
      • DSM 16:25
        6h 16m
        1 stop
        BUF 23:41
        Des Moines - Buffalo | Thu, Jan 8 | American Airlines
        BUF 18:53
        5h 15m
        1 stop
        DSM 23:08
        Buffalo - Des Moines | Mon, Jan 12 | American Airlines
        THB 9,970
        18% OFF
        THB 12,160 THB 9,970
      • DSM 08:00
        4h 24m
        1 stop
        BUF 13:24
        Des Moines - Buffalo | Fri, Jan 30 | United Airlines
        BUF 08:30
        7h 3m
        1 stop
        DSM 14:33
        Buffalo - Des Moines | Mon, Feb 2 | United Airlines
        THB 10,149
        17% OFF
        THB 12,160 THB 10,149
      • DSM 16:07
        7h
        1 stop
        BUF 00:07
        Des Moines - Buffalo | Thu, Dec 11 | American Airlines
        BUF 19:15
        6h 22m
        1 stop
        DSM 00:37
        Buffalo - Des Moines | Thu, Dec 18 | American Airlines
        THB 10,257
        16% OFF
        THB 12,160 THB 10,257
      • DSM 06:24
        4h 21m
        1 stop
        BUF 11:45
        Des Moines - Buffalo | Thu, Jan 29 | Delta Air Lines
        BUF 06:03
        4h 38m
        1 stop
        DSM 09:41
        Buffalo - Des Moines | Sun, Feb 1 | Delta Air Lines
        THB 10,401
        14% OFF
        THB 12,160 THB 10,401
      • DSM 06:40
        4h 22m
        1 stop
        BUF 12:02
        Des Moines - Buffalo | Thu, Jan 1 | American Airlines
        BUF 05:12
        8h 34m
        1 stop
        DSM 12:46
        Buffalo - Des Moines | Thu, Jan 8 | American Airlines
        THB 10,661
        12% OFF
        THB 12,160 THB 10,661
      • DSM 08:00
        4h 24m
        1 stop
        BUF 13:24
        Des Moines - Buffalo | Thu, Jan 8 | United Airlines
        BUF 08:30
        7h 3m
        1 stop
        DSM 14:33
        Buffalo - Des Moines | Thu, Jan 15 | United Airlines
        THB 10,728
        12% OFF
        THB 12,160 THB 10,728
      • DSM 15:00
        7h 59m
        1 stop
        BUF 23:59
        Des Moines - Buffalo | Sat, Dec 13 | Delta Air Lines
        BUF 06:00
        5h 38m
        1 stop
        DSM 10:38
        Buffalo - Des Moines | Sun, Dec 14 | Delta Air Lines
        THB 10,944
        10% OFF
        THB 12,160 THB 10,944
      • DSM 13:00
        17h 25m
        1 stop
        BUF Invalid Date
        Des Moines - Buffalo | Sat, Dec 13 | Normal Airline
        BUF 15:00
        6h
        Direct
        DSM 16:00
        Buffalo - Des Moines | Mon, Dec 15 | Normal Airline
        Find More Flights
        Find More Flights
      • DSM 18:14
        14h 7m
        1 stop
        BUF 09:21
        Des Moines - Buffalo | Wed, Jan 14 | Allegiant Air
        THB 4,265 THB 6,304
        32% OFF
        32% OFF
        THB 6,304 THB 4,265
      • DSM 17:16
        5h 12m
        1 stop
        BUF 23:28
        Des Moines - Buffalo | Thu, Jan 22 | Delta Air Lines
        THB 4,444 THB 6,304
        30% OFF
        30% OFF
        THB 6,304 THB 4,444
      • DSM 11:14
        10h 27m
        1 stop
        BUF 22:41
        Des Moines - Buffalo | Tue, Dec 23 | Frontier Airlines
        THB 4,547 THB 6,304
        28% OFF
        28% OFF
        THB 6,304 THB 4,547
      • DSM 08:00
        10h 28m
        1 stop
        BUF 19:28
        Des Moines - Buffalo | Mon, Jan 5 | Allegiant Air
        THB 4,758
        25% OFF
        THB 6,304 THB 4,758
      • DSM 06:24
        4h 18m
        1 stop
        BUF 11:42
        Des Moines - Buffalo | Sat, Jan 17 | Delta Air Lines
        THB 4,848
        23% OFF
        THB 6,304 THB 4,848
      • DSM 17:21
        5h 7m
        1 stop
        BUF 23:28
        Des Moines - Buffalo | Tue, Dec 23 | Delta Air Lines
        THB 4,866
        23% OFF
        THB 6,304 THB 4,866
      • DSM 17:15
        5h 42m
        1 stop
        BUF 23:57
        Des Moines - Buffalo | Tue, Jan 6 | Delta Air Lines
        THB 4,898
        22% OFF
        THB 6,304 THB 4,898
      • DSM 16:07
        7h
        1 stop
        BUF 00:07
        Des Moines - Buffalo | Thu, Dec 11 | American Airlines
        THB 5,162
        18% OFF
        THB 6,304 THB 5,162
      • DSM 17:16
        5h 42m
        1 stop
        BUF 23:58
        Des Moines - Buffalo | Mon, Jan 12 | Delta Air Lines
        THB 5,302
        16% OFF
        THB 6,304 THB 5,302
      • DSM 08:00
        4h 24m
        1 stop
        BUF 13:24
        Des Moines - Buffalo | Thu, Jan 8 | United Airlines
        THB 5,674
        10% OFF
        THB 6,304 THB 5,674
      • DSM 13:00
        17h 25m
        1 stop
        BUF Invalid Date
        Des Moines - Buffalo | Sat, Dec 13 | Normal Airline
        Find More Flights
        Find More Flights

Displayed flight fares from Des Moines to Buffalo are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Flight details for Des Moines to Buffalo

The distance between Des Moines and Buffalo is 1,236.99 km. Based on Trip.com's data, travel demand peaks in July. The off-season for travel is September.

Cheapest one-way flight priceTHB 4,265
Cheapest round-trip ticket priceTHB 6,994
Off-season for travelSeptember
Peak season for travelJuly
Flight distance1,236.99 km
Popular airlineDelta Air Lines

Find the best time to fly from Des Moines to Buffalo

The cheapest time for Des Moines to Buffalo flights: Jan 11 to Jan 18 — one way flight prices from THB 4,264.

Cheapest flights
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  • 714
  • 1421
  • 2128

  • Jan

    284
  • 411
  • 1118
  • 1825

  • Feb

    251
  • 18
  • 815
  • 1522

  • Mar

    221
Displayed fare trends are based on Trip.com's aggregated average of the lowest flight prices from Des Moines to Buffalo, calculated over the upcoming 10 weeks.

Flight FAQs

  • What are the cheapest flights from Des Moines to Buffalo (DSM-BUF)?

    Based on Trip.com data, Allegiant Air offers one-way fares as low as THB 4,265 on Cheapest nonstop routes (e.g. DSM to BUF on Wed, Jan 14), while American Airlines offers Cheapest nonstop round-trips from THB 6,994 departing on Sat, Jan 17 and returning on Sat, Jan 24.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Des Moines to Buffalo is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Des Moines to Buffalo, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Jan 14, with one-way flights priced at just THB 4,265.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Allegiant Air.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Buffalo travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Des Moines to Buffalo is September, when demand for travel is lower.
  • After crunching the numbers on our December flight calendar, it's currently cheapest to fly from Des Moines to Buffalo on December 23, 2025 with Frontier Airlines, with prices starting at THB 4,546.
  • The time difference between Buffalo and Des Moines is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.